Samuel Jessurum de Mesquita received his artistic education at the Rijksnormaalschool voor Teekenonderwijs. In additon he followed lessons at the Rijksschool voor Kunstnijverheid in Amsterdam. One of his fellow students was his future brother in law, Joseph Mendes da Costa.
From 1889 onwards, he began producing ‘sensitive' drawings, drawings with bizarre and caricaturist representations which had an evidently graphic character. Later on in his career he developed these into etchings, lithographies and woodcarvings. He experimented with his etching technique in marble, for example. He began woodcarving in 1896.